一、基本情况
唐国涛，药剂学博士；讲师，硕士生导师。主要肿瘤微环境响应小分子药物的设计合成与开发，肿瘤微环境响应药物给药系统的研究与开发。先后承担国家湖南省自然科学基金、湖南省教育厅重点项目、企业合作（委托）等课题。在Eur. J. Med. Chem.，Bioor. Chem等杂志发表研究论文20余篇，授权专利3项。
Email: tgtzq@163.com
二、研究领域
1. 肿瘤微环境响应小分子药物的设计合成与开发。
2. 肿瘤微环境响应药物给药系统的研究与开发。
三、工作及学习经历
2004.7-至今 南华大学，yl23455永利(中国)有限公司，讲师
2006.9-2010.1 复旦大学，yl23455永利(中国)有限公司，博士
2001.9-2004.7 湖北中医药大学，中药系，硕士
1997.07-2001.04，江苏康缘药业
1993.9-1997.7 湖北中医学院，中药系，药士
四、社会兼职
无
五、教学工作
目前承担课程：中医药学概论、制药工艺与工程。
六、承担课题
1.新型抗体药物及其智能运输系统湖南省重点实验室开放课题，2022-KL02,苯甲酸修饰的苯并咪唑类LDHA抑制剂的设计合成与抗肿瘤活性研究.2022.10-2024.09,10万，在研，主持。
2.湖南省教育厅, 重点项目, 22A0304, 含芳基脲结构的YC-1衍生物的设计、合成及抗肿瘤活性评价, 2023.01-2025.12, 8万元, 在研, 主持
3.湖南省自然科学基金面上项目，2020JJ4534，含芳基脲结构的三甲氧基黄酮衍生物的合成及抗肿瘤活性研究，2020-2022，5.0万，已结题，主持
七、代表性文章
1.Senyi Liao; Guang Wu; Zhizhong Xie; Xiaoyong Lei; Xiaoyan Yang; Sheng Huang; Xiangping Deng; Zhe Wang; Guotao Tang. pH regulators and their inhibitors in tumor microenvironment. European Journal of Medicinal Chemistry, 2024, 267: 116170
2.Jing Zhang; Jia Yu; Meijing Liu; Zhizhong Xie; Xiaoyong Lei; Xiaoyan Yang; Sheng Huang; Xiangping Deng; Zhe Wang; Guotao Tang. Small-molecule modulators of tumor immune microenvironment. Bioorganic Chemistry, 2024, 145: 107251.
3.Yiyang Li; Zhizhong Xie; Xiaoyong Lei; Xiaoyan Yang; Sheng Huang; Weixi Yuan; Xiangping Deng; Zhe Wang; Guotao Tang. Recent advances in pyruvate dehydrogenase kinase inhibitors: Structures, inhibitory mechanisms and biological activities. Bioorganic Chemistry, 2024, 144: 107160.
4.Chenglin Ouyang; Jing Zhang; Xiaoyong Lei; Zhizhong Xie; Xingyun Liu; Yong Li; Sheng Huang; Zhe Wang*; Guotao Tang*. Advances in antitumor research of HIF-1α inhibitor YC-1 and its derivatives. Bioorganic Chemistry, 2023, 133: 106400
5.Yang Zou; Na Lu; Xiaoyan Yang; Zhizhong Xie; Xiaoyong Lei; Xingyun Liu; Yong Li; Sheng Huang; Guotao Tang; Zhe Wang. Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives. RSC Med. Chem., 2023, 14, 1172–1185.
6.Xueyan Sun; Zhizhong Xie; Xiaoyong Lei; Sheng Huang; Guotao Tang; Zhe Wang. Research and development of N,N′-diarylureas as anti-tumor agents. RSC Med. Chem., 2023, 14, 1209–1226.
7.Xueyan Sun; Yin Zhao; Jingduo Zhao; Zhizhong Xie; Xiaoyong Lei; Xingyun Liu; Yong Li; Sheng Huang; Zhe Wang*; Guotao Tang*. Design, synthesis, and antitumor evaluation of trimethoxyflavonoid with arylurea structure against hepatocellular carcinoma. Drug Development Research, 2023, 84:406–422.
8.Xiangping Deng; Yang Zou; Renbo Liu; Yijiao Peng; Chenglin Ouyang; Junmei Peng; Xiaoyong Lei; Zhizhong Xie; Chong Li*; Guotao Tang*. Discovery of a Potential Multi-Target Anti-Tumor Agent via Structural Modification on Flavonoid. Polycyclic Aromatic Compounds, 2023, 43(2): 980-999.