一、基本情况

姚旭，药理学硕士；实验师。主要从事天然产物的结构修饰及抗癌活性的研究。承担湖南省教育厅一般项目1项。

Email: 355938360@qq。com

二、研究领域

1.天然产物的结构修饰：主要进行黄酮类化合物的结构修饰及其抗癌活性。

三、工作及学习经历

2015/1--至今，南华大学，yl23455永利(中国)有限公司，实验师

2011/8-2014/12，南华大学，yl23455永利(中国)有限公司，助理实验师

四、教学工作

负者药学实验中心的日常管理、运行和维护，承担了药学实验中心实验实验课程准备工作。

五、承担课题

1. 湖南省教育厅科学研究项目，18C0438，含氟白杨素衍生物的设计、合成及其抗乳腺癌活性研究，2019/01-2020/12，结题，主持。

六、代表性文章

1) Cai-Hong Tang, Yue Zeng, Jian-Xin Zhang, Xing Zheng, Feng Tang, Xu Yao,* Zhong-Xing Jiang,*Wei Shi,* Wei Huang, One-Pot Assembly of Dual-Site-Specific Antibody−Drug Conjugates via Glycan Remodeling and Affinity-Directed Traceless Conjugation, Bioconjugate Chem. 2023, 34, 748-755.

2) Ying-Li Zhu, Fan Zheng, Can Xiao, Xiao-He Liu, Xu Yao*, Wen-Bin Zeng, Synthesis and Bio-evaluation of 2-Alkyl Substituted Fluorinated Genistein Analogues against Breast Cancer, Med Chem. 2022, 18(5): 589-601.

3) Zhi-Fang Yang, Yi Liu, Zhuo Liu, Qin-Fang Xu, Shun Liu , Kai-Lin Jiang, Yuan-Long Shi, Wen-Yu Xu, Ze-Hua Yang, Peng-Bing Mi, Yi-Jun Xiang,* , Xu Yao,* Xing Zheng*, Design, synthesis, and anti-breast cancer activity of novel fluorinated 7-O-modified genistein derivatives. Med Chem, 2023,19(1), 64-74.

4) Li Song, Ling Dai, Yan Tan, Kai-Lin Jiang, Xue-Ni Wei, Yu-Fei Hu, Ya-Lin Hu, Jie-Ying Lin, Xu Yao*, Peng-Bing Mi*, Xing Zheng*, Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers, Medicinal Chemistry Research, 2023, 32(11), 2279-2298.

5) Yi-Li Dai, Lin-Jun Sun, Yan Tan, Wen-Yu Xu, Shu Liu, Jing Zhou, Ya-Lin Hu, Jie-Ying Lin, Xu Yao*, Peng-Bing Mi*, Xing Zheng*, Recent progress in the development of ursolic acid derivatives as anti-diabetes and anti-cardiovascular agents, Chem Biol Drug Des. 2023, 102(6), 1643-1657.